Advances in Immunology, Vol. 46 by Frank J. (Editor) Dixon PDF

By Frank J. (Editor) Dixon

ISBN-10: 0120224461

ISBN-13: 9780120224463

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Extra info for Advances in Immunology, Vol. 46

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This novel joining results in additional diversity of the final &chain variable region. 1. Organization of the Mouse a- and &Chain Loci The mouse a-and 6-chain gene families are located at chromosomal position 14C-D as summarized in Table I. The physical map of these loci is shown in Fig. 13. , 1988). In contrast, only 3 of 17 mouse Vp gene segment subfamilies have multiple members. Preliminary data indicate that V, gene segment subfamily members may be interspersed as previously observed for the mouse 0-chain locus (K.

The D and L genes encode the H2-D and H2-L proteins, respectively. The Tla regions have been mapped distal to the Qu region by restriction fragment length polymorphism (Winoto et u l . , 1983). , 1985). The distances between the Tlu and Qu regions have not been determined; however, recent data suggested that the Tla cluster containing T1 through Tll is located within 500 kb of the Qu region, and the two Tlu clusters are within 250 kb (E. Straus, S. Hunt, E. Lai, and L. Hood, unpublished results).

The first cluster contains three and the second cluster contains two J, gene segments. The Jy-C, clusters span slightly more than 30 kb of DNA. Like most of the other immunoglobulin-like loci, there are no V, gene segments located 3’ of the constant region genes. c. a- AND &CHAIN GENEFAMILIES Functional mouse and human T cell receptor a-chain variable regions are encoded by V, and Ja gene segments. Like the Vg and V, gene segments described above, V, gene segments consist of a small leader exon and a large second exon separated by an intron of 100 to 400 bp.

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Advances in Immunology, Vol. 46 by Frank J. (Editor) Dixon

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