By David C. Whitcomb MD PhD, Adam Slivka MD, Kenneth K. Lee
Problems of the pancreas have, long ago, been very problematical as the prognosis used to be frequently made past due through the illness and no considerably useful interventions have been to be had. this case is swiftly altering as new insights from a number of views are built-in and interested by every one step of this advanced approaches. This factor of Gastroenterology Clinics of North the USA highlights a couple of components of speedy development in inflammatory and neoplastic problems of the pancreas. every one bankruptcy represents the built-in wisdom and standpoint of specialists within the box, and signify the hottest research of those cutting-edge methods to advanced matters within the overview and remedy of pancreatic issues.
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Additional info for Advances in the Diagnosis and Treatment of Pancreatic Diseases, An Issue of Gastroenterology Clinics Vol 36 Issue 2
Several centers reported segmental narrowing of the 250 KRASINSKAS, RAINA, KHALID, ET AL main pancreatic duct, in addition to cases with diffuse narrowing. With the discovery that AIP is an IgG4-related disease, IgG4 levels were incorporated into the diagnostic criteria. Knowing that AIP is responsive to steroid therapy, unlike other forms of pancreatitis and pancreatic cancer, some centers incorporated the response to steroid therapy as a diagnostic criterion. The Japanese have recently proposed a revision of their diagnostic criteria, emphasizing that malignancy must be excluded; they also site the importance of extrapancreatic lesions and associated disorders (Box 3) .
SUMMARY AIP is a benign, IgG4-related, fibroinflammatory form of chronic pancreatitis that can mimic pancreatic ductal adenocarcinoma both clinically and AUTOIMMUNE PANCREATITIS 253 radiographically. Clinically, AIP most commonly presents as obstructive jaundice associated with a biliary stricture and tends to respond to steroid therapy. Radiographically, AIP can appear as a focal lesion or mass, or can diffusely involve the pancreas (on CT or MRI) with associated focal or diffuse narrowing of the pancreatic duct (on ERCP).
Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses. Am J Gastroenterol 2006; 101(11):2493–500. AUTOIMMUNE PANCREATITIS 257  Finkelberg DL, Sahani D, Deshpande V, et al. Autoimmune pancreatitis. N Engl J Med 2006;355(25):2670–6.  Padilla D, Cubo T, Villarejo P, et al. Response to steroid therapy of sclerosing cholangitis after duodenopancreatectomy due to autoimmune pancreatitis. Gut 2005;54(9):1348–9.  Toosi MN, Heathcote J.
Advances in the Diagnosis and Treatment of Pancreatic Diseases, An Issue of Gastroenterology Clinics Vol 36 Issue 2 by David C. Whitcomb MD PhD, Adam Slivka MD, Kenneth K. Lee