Download e-book for kindle: Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham,

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

ISBN-10: 1848826362

ISBN-13: 9781848826366

Understanding the various complicated mobile and molecular mechanisms underlying human vascular ailments is key in enhancing the administration of sufferers with this clinically very important and wide-ranging team of ailments. this can be really vital while contemplating the level of this factor around the world.

Written through a crew of world-renowned gurus, Advances in Vascular Medicine highlights the various relationships among simple technology and medical drugs, and reports either examine and medical perform tools and results in vascular biology and pathobiology. it really is an authoritative reference for those vital themes of vascular biology and comprises chapters that designate the scientific concerns to the elemental scientist in addition to delivering clinicians with a systematic grounding in vascular illnesses. even supposing there's nonetheless a lot paintings to be performed to enhance knowing of vascular illness, the data and insights contained during this ebook are a necessary contribution to the literature, giving scientists and clinicians the chance to benefit extra approximately this intriguing box of biomedicine.

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J Lipid Res. 2003;44:878–883. 11. Burnett JR, Shan J, Miskie BA, et al. A novel nontruncating APOB gene mutation, R463W, causes familial hypobetalipoproteinemia. J Biol Chem. 2003;278:13442–12352. 1 Oligonucleotide Therapeutics to Treat Dyslipoproteinemia and Atherosclerosis 21 12. Tarugi P, Lonardo A, Ballarini G, et al. 5). J Hepatol. 2000;33:361–370. 13. Zamel R, Khan R, Pollex RL, Hegele RA. Abetalipoproteinemia: two case reports and literature review. Orphanet J Rare Dis. 2008;3:1. 14. Ng DS, Leiter LA, Vezina C, Connelly PW, Hegele RA.

2000;1494:1–13. 3. Olofsson SO, Asp L, Boren J. The assembly and secretion of apolipoprotein B-containing lipoproteins. Curr Opin Lipidol. 1999;10:341–346. 4. Owen JS, Mulcahy JV. ATP-binding cassette A1 protein and HDL homeostasis. Atheroscler Suppl. 2002;3:13–22. 5. Rader DJ. Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest. 2006;116:3090–3100. 6. Rye KA, Barter PJ. Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I.

B) Splice site selection can be blocked artificially using antisense oligonucleotides (ASO), for example (as shown) by targeting an exonic splicing enhancer (ESE) or silencer (ESS) element. 40 Although RNA interference successfully reduced plasma LDL, it is uncertain whether impaired production of chylomicrons might cause liver toxicity and intestinal dysfunction as is sometimes observed in FHBL patients. 40 Although ApoB87Padova produces functional LDL particles, they have much faster catabolic rates and hence FHBL kindreds have markedly decreased plasma LDL and total cholesterol.

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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)


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